Although PPFIBP1 has a pLI of 0 and a pHaplo of 0.81 (Table 3)—values consistent with its autosomal recessive disease mechanism— and has a OD < 0 for intellectual disability in the heatmap (Figure 2A), a role in the psychomotor deficit observed in 12p-deleted patients cannot be entirely excluded, particularly in the context of a multigene deletion syndrome. The gene discussed is PPFIBP1; the disease is Intellectual disability.