Another interesting new gene from a neurodevelopmental perspective is DENN domain containing 5B (DENND5B, *617279, cytoband 12p11.21): this gene, positively associated with intellectual disability, dental anomalies and facial dysmorphism in Figure 2A, encodes a member of the DENND5 protein subfamily that seems to contribute to synaptic plasticity through the modulation of synaptic vesicles, axonal trafficking, and neurotransmitter release [25]. Here, DENND5B is linked to Intellectual disability.