COL5A1 and keratoconus: A large sequencing study in 2021 provided strong evidence of a shared genetic etiology between KC and EDS: in a cohort of approximatively 745 KC patients (and 810 controls), researchers resequenced 34 candidate genes and found a significant enrichment of rare variants in COL5A1, COL12A1, TNXB, and ZNF469—all genes known to cause various subtypes of EDS [41].