Among the SNVs included in the PRS for SLE, several correspond to well-established SLE susceptibility loci genes such as IRF5, STAT4, IKZF1/2/3, TYK2, TNFAIP3, TNIP1, BLK, BANK1 and PTPN22, all consistently replicated across large GWAS meta-analyses and considered core components of the genetic architecture of SLE [4,19] (Table S2). The gene discussed is IRF5; the disease is systemic lupus erythematosus.