CRX and retinitis pigmentosa 1: Future studies should explore (1) the prognostic significance of nasal degeneration, (2) whether environmental factors or modifier genes are necessary for the development of the nasal degeneration phenotype, (3) whether specific loci and variant subtypes in the CRX gene are associated with nasal degeneration in a larger cohort, and (4) whether a subset of RCD/RP patients also exhibit nasal retinal degeneration.