Conversely, the loss of HNF4α expression and function (due to inflammation, oncogenic signaling, extracellular cues or loss of epithelial identity), contributes to pathological states, highlighting that the restoration of HNF4α-driven epigenetic regulations may represent a promising strategy for therapeutic intervention, particularly for cancer, where HNF4α-mediated regulation of epithelial identity and EMT is frequently disrupted. Here, HNF4A is linked to cancer.