Furthermore, HNF4α impairment is implicated in the development of organ fibrosis (i.e., liver and renal fibrosis) [97,98] and in the onset of various cancers, including hepatocellular carcinoma, renal cell carcinoma, and pancreatic ductal adenocarcinoma [99,100]. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.