Interestingly, miR-29a has also been reported to upregulate the Hippo pathway through the relief of DNMT3B-mediated LATS1 methylation in HCC, thus interfering with YAP expression [53], and potentially with the YAP-mediated HNF4α downregulation [54]. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.