On multivariate logistic regression, albumin < 3.5 gm/dL was significantly associated with reoperation (OR = 1.39, <i>p</i> = 0.031), prolonged hospitalization (OR = 1.28, <i>p</i> = 0.038), and 30-day mortality (OR = 1.74, <i>p</i> = 0.025).<h4>Conclusions</h4>Preoperative hypoalbuminemia is independently associated with increased morbidity and mortality following radical cystectomy. The gene discussed is ALB; the disease is Hypoalbuminemia.