FAP and neoplasm: Mechanistically, miR-624-5p bound to FAP mRNA and negatively regulated FAP expression (<i>p</i> < 0.001), thus suppressing CAF activation and tumor metastasis.<h4>Conclusions</h4>Our findings establish miR-624-5p as a novel upstream regulator that suppresses FAP expression, consequently inhibiting CAF activation and its pro-metastatic function.