<b>Results:</b> Rosacea patients showed higher NLR, PLR, SII, PIV, MPV, CRP, and LDL cholesterol (<i>p</i> < 0.05) and lower SIRT1, SIRT3, visfatin, and irisin (<i>p</i> < 0.01). Here, SIRT1 is linked to rosacea.