While the most prevalent sub-category includes corticotherapy, another important (endocrine) contributor is represented by Cushing’s syndrome caused by cortisol-producing adrenal tumours, by adrenocorticotropic hormone (ACTH)–secreting pituitary tumours (Cushing’s disease), or, to a lesser extent, by paraneoplastic Cushing’s syndrome accompanying various malignancies (e.g., lung out cell carcinoma, medullary thyroid cancer, or other neuroendocrine neoplasia) [3,4,5,6,7,8,9,10]. This evidence concerns the gene POMC and Cushing syndrome.