miR-1908-5p overexpression lowers SCAMP4, which is overexpressed in tumor tissues and exhibits an inverse correlation with miR-1908-5p.<h4>Conclusion</h4>miR-1908-5p is downregulated in CRC, correlates with TNM stage, nodal metastasis, elevated CA19-9 levels, and poor survival, and suppresses CRC cell proliferation, migration, and invasion by directly targeting SCAMP4, thereby qualifying as a potential prognostic biomarker for CRC. The gene discussed is SCAMP4; the disease is neoplasm.