DRAM2 and breast cancer: In contrast, the following genes exhibited significantly reduced expression in breast cancer tissues (Fig 1B): ATG2B, ATG9A, ATG10, ATG14, DEPP1, NBR1, RUBCNL, ATG4C, DRAM1, DRAM2, EPG5, FYCO1, ULK2, and ELAPOR2.Somatic mutations were detected in 704 of 1, 103 samples (64%).