Similar findings as in the CHS model (Fig. 2) suggesting the contribution of LECs to the plasmin-mediated conversion of CCL21-ΔC were also made in an alternative murine inflammation model, namely, upon inducing skin inflammation by topical application of the irritant 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent protein kinase C activator (Friess et al., 2022; Nakadate, 1989). Here, CCL21 is linked to inflammatory response.