GAD1 and major depressive disorder: Interestingly, the DeltaEE and DeltaDP were not associated with changes in depression severity (DeltaPHQ-8, computed as PHQ-8 total score at the end of the study minus the PHQ-8 total score at the start of the study) or anxiety (DeltaGAD-7 computed as GAD-7 total score at follow-up minus GAD-7 total score at baseline).