For example, peptides containing the ‘CendR’ motif, such as tLyP-1 (CGNKRTR), bind to neuropilin-1 (NRP-1)—a receptor involved in tumor angiogenesis and metastasis—exhibiting tumor-specific tissue penetration and up to 4.8-fold increased tumor accumulation, as validated by SPECT/CT imaging [91]. The gene discussed is NRP1; the disease is neoplasm.