Among immune regulators, tumor-associated macrophages (TAMs) constitute a major component of the TME, promoting tumor cell invasion, angiogenesis, and immune evasion through the secretion of cytokines such as interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF) [14,15,16]. This evidence concerns the gene IL6 and neoplasm.