CRP and obesity due to melanocortin 4 receptor deficiency: As the first meta-analysis to evaluate HIT’s influence on inflammatory cytokines in this population, subgroup analyses further identified that protocols with a work-to-rest ratio of at least 1:1 and sessions lasting 20 min or less were most effective for reducing CRP, aligning with findings from Cao et al. [13] Meanwhile, the results reinforce previous meta-analyses that investigated various health and disease conditions, confirming that HIT can reduce CRP levels [40], even in children with obesity.