Thus, the inhibition of TSP-1 may prevent atrial fibrogenesis: for instance, inhibition of the TSP-1 and TGF-β1 complex association between TSP-1 and LSKL peptide reduced myocardial fibrosis and enhanced cardiac performance in a preclinical model [88,89,90]. This evidence concerns the gene TGFB1 and Myocardial fibrosis.