Meanwhile, insulin was negatively correlated (r = −0.58 to −0.65) with several phospholipid metabolites (including PC 36:3, lysophosphatidylcholine (LPC 20:1), and LPC 17:2), suggesting that BCAA supplementation may influence insulin signaling through the modulation of membrane lipid metabolism, a notion supported by established links between dysregulated lipid metabolism and insulin resistance [9]. This evidence concerns the gene INS and Insulin resistance.