High-risk 1 (H1): higher age, multiple organ dysfunction, especially cardiac and respiratory failure; high mortalityHigh-risk 2 (H2): younger age, liver dysfunction, and coagulopathy; higher levels of IL6, angiopoietin-2, thrombomodulin, and vWF; higher mortalityModerate risk: older age, pneumonia, and neurologic dysfunctionLow-risk 1 (L1): younger age, fluid-refractory, few other organ dysfunctions, and low mortalityLow-risk 2 (L2): younger age, fluid-responsive, and low mortality. The gene discussed is ANGPT2; the disease is pneumonia.