For example, combining CA-125 with hematologic ratios (e.g., PLR) yielded better diagnostic performance in some studies: in one analysis of ovarian endometriosis, a combined marker (CA-125/PLR) achieved 83.4% sensitivity and 95.8% specificity (AUC ~0.91), outperforming either marker alone [39]. The gene discussed is MUC16; the disease is ovarian endometriosis.