AKT1 and neoplasm: For example, anti-tumor activity is a promising direction: Many natural products with cyclic scaffolds similar to tetronates have been reported to inhibit tumor cell proliferation, induce apoptosis, or suppress angiogenesis by targeting key signaling pathways (e.g., PI3K/Akt, MAPK) or enzymes (e.g., topoisomerase, histone deacetylase) [19].