In both experimental models and in patients, it has been shown that a Th1-type response characterized by the production of IFN-γ and TNF-α is essential for macrophage activation and intracellular elimination of the fungus, while a Th17 profile, mediated by IL-17 and IL-22, contributes to neutrophil recruitment and early control of infection [100,115,116]. Here, IFNG is linked to infection.