Studies have shown that TAMs in this niche exhibit heterogeneous but predominantly M2-like phenotypes, producing immunosuppressive and tumor-supporting mediators, including TGF-β, IL-6, IL-10, CCL18, fibronectin, and tenascin C—molecules that favor tumor cell spheroid formation, migration, and the development of chemoresistance [87,88]. This evidence concerns the gene TNC and neoplasm.