Wogonoside increased PLSCR1 expression and its binding to the 1, 4, 5-trisphosphate receptor 1 (IP3R1) promoter in primary AML cells. Activation of IP3R1 by wogonoside promoted Ca2+ release from the endoplasmic reticulum, contributing to cell differentiation. Here, ITPR1 is linked to acute myeloid leukemia.