In PML/RARα mice, EGCG administration reversed anemia, leukocytosis, and thrombocytopenia, and prolonged survival. In NB4 cells, EGCG upregulated neutrophil differentiation markers (CD11b, CD14, CD15, CD66) and, together with N-acetyl-L-cysteine (NAC), inhibited ROS production. This evidence concerns the gene ITGAM and Increased total leukocyte count.