Resveratrol (10 μM, 3 days) promoted CD11b expression in HL-60, NB4, U937, THP-1, and ML-1 cells, with additive effects observed upon co-treatment with ATRA or vitamin D3. At 20 μM, it induced NBT reduction and morphological differentiation in 8 of 19 primary leukemia samples. The gene discussed is ITGAM; the disease is leukemia.