SERPINE1 and hyperinsulinemic hypoglycemia, familial, 4: In conditions such as von Willebrand disease (VWD), haemophilia carriership, rare platelet function disorders (e.g., Bernard-Soulier syndrome), and fibrinolytic defects (e.g., plasminogen activator inhibitor-1 deficiency), the normal physiological adaptations of pregnancy (rise in clotting factors, increased platelet reactivity) are blunted or insufficient [5].