Sebestjen et al. investigated biomarkers of hypofibrinolysis in FH individuals with and without CHD and found significantly higher levels of tissue plasminogen activator (t-PA) antigen and plasminogen activator inhibitor-1 (PAI-1) antigen—both suppressors of fibrinolysis—in FH individuals with CHD. Here, SERPINE1 is linked to familial hyperaldosteronism.