Previous systematic reviews and meta-analyses, including those by Kumar et al. (2025) and Lv et al. (2021), have reported a high diagnostic accuracy of interleukin-6 (IL-6) and angiopoietin-2 (Ang-2) when evaluated as individual predictors of severe acute pancreatitis and organ failure [21,22]. This evidence concerns the gene ANGPT2 and acute pancreatitis.