This study presents the development and evaluation of multifunctional, thermoresponsive nanogels based on poly(N-vinylcaprolactam-co-N-vinylpyrrolidone) (P(NVCL-co-NVP)) with a poly(ethylene glycol) methyl ether methacrylate (PEGMA) shell and galactose (GAL) targeting ligand for colon cancer therapy. This evidence concerns the gene GAL and malignant colon neoplasm.