The results showed that the expression levels of IGF2BP3 and CENPA were positively correlated with the levels of immune exhausted and immunosuppressive nTreg and iTreg cells (Figure 5B), demonstrating the inhibitory role of IGF2BP3 and CENPA in tumor immunity, and that immune exhaustion may lead to poorer prognosis for patients. This evidence concerns the gene CENPA and neoplasm.