Importantly, isoliquiritigenin, an extract from licorice, effectively inhibited ANXA2 expression in muscle (p < 0.05), alleviated muscle atrophy (p < 0.05) and motor incoordination (p < 0.05), while showing no adverse effects on anxiety-like behaviours associated with CB2R (p > 0.05).<h4>Conclusions</h4>ANXA2 is a key mediator of the muscle-cerebellum axis in sarcopenia, contributing to muscle atrophy by downregulating Neu2 and motor incoordination by targeting CB2R. This evidence concerns the gene ANXA2 and Anxiety.