However, in multivariate logistic regression models adjusted for age, sex, and BMI, the APOE × APOA1 interaction term did not reach statistical significance (p = 0.138).<h4>Conclusion</h4>APOE ε4 and APOA1 rs5069 A alleles were independently associated with obesity-related T2DM. This evidence concerns the gene APOA1 and obesity due to melanocortin 4 receptor deficiency.