The key objectives of the current study were to investigate glial activation, neuroinflammation, OS, cytotoxicity, neuronal apoptosis, and the neuroprotective potential of Os_9aa in NSE-hαSyn/MPTP-induced mouse PD models using behavioral experiments, biochemical assays, western blotting, and immunofluorescence. The gene discussed is ENO2; the disease is Parkinson disease.