APP and nevus comedonicus syndrome: Data analysis was performed from January 2024 to November 2025.<h4>Exposures</h4>RHI history and CTE-NC presence.<h4>Main outcomes and measures</h4>Informant-reported clinical history as well as symptoms and immunohistochemistry for phosphorylated tau (p-tau), phosphorylated TAR DNA-binding protein 43 (p-TDP-43), α-synuclein, and amyloid-β (Aβ), as well as amyloid precursor protein and human leukocyte antigen DR.<h4>Results</h4>Of 70 autopsied individuals (62 male, 8 female; mean [SD] age, 64.40 [13.94] years), 20 showed CTE-NC in the brain.