Consistent with this, stress-independent activation of XBP1s, or especially, ATF6 has been shown to correct pathologic imbalances in ER quality control implicated in the pathogenesis of many different protein misfolding diseases, including those indicated above (Chen et al., 2014; Cooley et al., 2014; Plate et al., 2019). This evidence concerns the gene ATF6 and proteostasis deficiencies.