GH1 and isolated congenital growth hormone deficiency: <h4>Objective</h4>To evaluate health-related quality of life (HRQoL) in adolescents with idiopathic isolated growth hormone deficiency (IIGHD) who tested GH-sufficient, comparing those who discontinued recombinant human growth hormone (rhGH) at mid-puberty with those who continued until near-adult height (NAH).<h4>Design</h4>This multicentre prospective study used a patient-preference design.