ALB and interstitial nephritis: 14.6 mg/kg body weight and above (♂):aspartate aminotransferase activity ↓, relative and absolute liver weights ↑,45.6 mg/kg body weight and above (♂):dilated tubules, renal granular casts, hyaline droplets, interstitial nephritis and papillary mineral deposition, centrilobular hepatocyte hypertrophy,52.5 mg/kg body weight and above (♀):relative and absolute liver weights ↑,133.7 mg/kg body weight (♂):platelet count ↑,blood urea nitrogen levels ↑,total protein, albumin, calcium levels ↑,relative and absolute kidney weights ↑,150.6 mg/kg body weight (♀):centrilobular hepatocyte hypertrophy