NFKB1 and neoplasm: Furthermore, its association with systemic inflammation and hepatic encephalopathy severity can be explained by its role as a potent source of LPS and its mechanistic link to carcinogenesis, potentially through TLR-mediated NF-κB activation and matrix metalloproteinase induction, facilitating tumor invasion and metastatic remodeling (Qin et al., 2014).