INS and Insulin resistance: We found that hesperidin supplementation significantly reduced the homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: −0.43, 95%CI: −0.82, −0.03; p = 0.034) and increased the quantitative insulin sensitivity check index (WMD: 0.05, 95%CI: 0.01, 0.08; p = 0.005).