In both PCOS and non-PCOS populations, euketonaemia (BHB ≥ 0.5 mmol/L - < 5 mmol/L) interventions have been associated with increased SHBG levels, alongside improvements in insulin sensitivity, glycaemic control, and androgen profiles (16–18, 29–35). This evidence concerns the gene INS and polycystic ovary syndrome.