No significant association was found between IGF-1 and ischemic stroke (RR = 1.69, 95% CI = 0.97–2.92, I2 = 82.2%, random-effects model, Figure 3), nor was there an impact of IGF-1 on unfavorable outcomes after ischemic stroke (RR = 1.55, 95% CI = 0.89–2.68, I2 = 86.6%, random-effects model, Figure 4). The gene discussed is IGF1; the disease is ischemic stroke.