We identified 15 survival-associated DEGs—MELK, NFE2L3, MCM2, MAD2L1, AUNIP, CXCL3, GLDN, GREM2, ALDH1A1, CILP, FABP4, AOC3, CNN1, ANGPTL1, and DES—as potential early diagnostic biomarkers for CRC. This evidence concerns the gene MCM2 and colorectal carcinoma.