CILP is an extracellular matrix protein that is abundant in cartilage tissue. It is primarily associated with musculoskeletal disorders, including osteoarthritis and lumbar disc degeneration (Mori et al., 2006), and most current studies focus on its role in connective tissue. At present, research on CILP in CRC is nearly nonexistent; however, Ye Jin Ha et al. identified CILP2 as a potential biomarker for predicting and targeting peritoneal metastasis in CRC (Ha et al., 2024). The gene discussed is CILP2; the disease is osteoarthritis.