Through the analysis of multiple TCGA datasets, ACSL6, AUNIP, CXCL3, CXCL8, CXCL11, EPHX4, GPR143, LRRC8, MAD2L1, MCM2, MELK, MMP3, and NFE2L3 were identified as potential therapeutic biomarkers for CRC. The gene discussed is MELK; the disease is colorectal carcinoma.