MAD2L1 and cancer: MAD2L1 is a tumor suppressor gene that can regulate the cell cycle and maintain the normal order of cell growth and division. In CRC, the downregulation of miR - 6787–5p (a microRNA that targets and controls MAD2L1) affects the expression of MAD2L1, thereby promoting the proliferation of cancer cells and the progression of CRC (Gharebaghi et al., 2024)