Previous studies have linked GLDN to hepatocellular carcinoma (Zhang et al., 2020) and gastric cancer (You et al., 2024; Liu et al., 2024). In CRC, Ying Su et al. identified GLDN as a prognostic biomarker for colon cancer based on machine learning and bioinformatics analysis (Su et al., 2022). This evidence concerns the gene GLDN and colonic neoplasm.