MAD2L1 is a tumor suppressor gene that can regulate the cell cycle and maintain the normal order of cell growth and division. In CRC, the downregulation of miR - 6787–5p (a microRNA that targets and controls MAD2L1) affects the expression of MAD2L1, thereby promoting the proliferation of cancer cells and the progression of CRC (Gharebaghi et al., 2024). The gene discussed is MAD2L1; the disease is colorectal carcinoma.