Through the analysis of multiple TCGA datasets, ACSL6, AUNIP, CXCL3, CXCL8, CXCL11, EPHX4, GPR143, LRRC8, MAD2L1, MCM2, MELK, MMP3, and NFE2L3 were identified as potential therapeutic biomarkers for CRC. This evidence concerns the gene EPHX4 and colorectal carcinoma.