For instance, studies demonstrated that imbalanced sphingolipid metabolism contributes to mitochondrial dysfunction and inflammatory amplification in an ALI model, while oxidized phospholipids promote pyroptosis through (Sun N. et al., 2024) the NLRP3 inflammasome pathway (Wang et al., 2025; Sun N. et al., 2024; Yeon et al., 2016). This evidence concerns the gene NLRP3 and acute respiratory distress syndrome.