BBR binds to the intracellular domain of transforming growth factor beta receptor 1 (TGFBR1) in pancreatic cancer, protecting endothelial barrier function from disruption induced by TGF-β1-overexpressing tumor cells and mitigating lung metastasis (Tian et al., 2022). This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.