LGS models carrying Gabrb3+/D120N and Gabrb3+/N328D mutations as well as infantile spasms syndrome (ISS) models carrying Gabrb3+/N110D mutations exhibited similar deficits in learning and memory, suggesting a cognitive deterioration phenotype typically seen in epileptic encephalopathies and progression of these genetic epilepsies (Nwosu et al., 2023; Qu et al., 2020; Qu et al., 2023). This evidence concerns the gene GABRB3 and Epileptic encephalopathy.