Studies by Liu et al. showed that polycyclic aromatic hydrocarbons like Benzo[b]fluoranthene (BbF), through activating the AhR pathway, not only lead to a significant increase in pro-inflammatory factors such as TNF-α, IL-1β, IL-6, and IL-8 but are also accompanied by oxidative stress and lipid metabolism disorders, creating a vicious cycle where inflammation and metabolic abnormalities mutually exacerbate each other (Liu et al., 2025). Here, AHR is linked to Disorder of lipid metabolism.