AKT1 and cardiac hypertrophy: Extensive evidence demonstrates that PI3K/Akt is a central regulator of cardiomyocyte function and survival, involving multiple aspects of inflammatory regulation, apoptosis, oxidative stress, and cardiac hypertrophy, and it plays an important regulatory role in the progression of cardiovascular disease (Cheng et al., 2021; Qin et al., 2021; Ren et al., 2020).