Additionally, early growth response factor 1 (EGR1) can bind to the promoter region of histone acetyltransferase EP300, upregulate EP300 expression, and enhance histone H3K27 acetylation, thereby inhibiting inflammation and apoptosis of PAECs and alleviating hypoxia-induced PAH (Yang et al., 2023). The gene discussed is EP300; the disease is pulmonary arterial hypertension.