The concentration specific to nrf2/hO-1 is shown in studies where low doses (1–10 μM) will activate Nrf2/H0-1 pathways causing antioxidant-driven liver model; at higher concentrations (20–50 μM), it causes Pro-oxidant Cytotoxicity by creating excessive levels of ROS while downregulating gpX4 and causing Feralptosis within cancer cells. Here, NFE2L2 is linked to cancer.