The effectiveness of AA on skin inflammation was also validated in an imiquimod-induced psoriasis model, where AA lowered the psoriasis area severity index (PASI) scores (e.g., by 30%–50% at 40 mg/kg), reduced epidermal thickness, rebalanced the Th17/Treg cell ratio in the spleen, and inhibited serum concentrations of IL-17A, IL-23, TNF-α and IL-1β (Li X. Q. et al., 2021). The gene discussed is TNF; the disease is psoriasis.