The m6A regulators YTHDC1 and HNRNPA2B1 were significantly up-regulated in peripheral blood mononuclear cells (PBMCs) of patients with T1DM compared with healthy individuals; however, METTL3 and IGF2BP2 were down-regulated in T1DM (23). This evidence concerns the gene YTHDC1 and type 1 diabetes mellitus.