YTHDF2 and familial dilated cardiomyopathy: However, another study found that METTL14 was down-regulated in cardiomyocytes and heart tissues of a DCM rat model with high-glucose (HG) treatment, and its overexpression suppressed pyroptosis and DCM by down-regulating the lncRNA TINCR with the participation of the m6A reader protein YTHDF2 (117).