Evident relevance was observed when the AST/ALT ratio was linked to ASCVD, CHD, ischemic stroke, and combined CHD and stroke in the univariate analysis, with ORs and 95% CIs of 1.374 (1.216–1.550) for ASCVD (P < 0.001), 1.213 (1.033–1.416) for CHD (P = 0.016), 1.414 (1.156–1.713) for ischemic stroke (P < 0.001), and 1.685 (1.335–2.100) for combined CHD and stroke (P < 0.001), respectively; however, these results were observed to be statistically nonsignificant in the adjusted model (all P > 0.05). The gene discussed is GPT; the disease is coronary artery disorder.